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KMID : 0438420080150010077
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Korean Journal of Bone Metabolism
2008 Volume.15 No. 1 p.77 ~ p.83
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Association of Prostaglandin-Endoperoxide Synthase 2 (PTGS2) Polymorphism with Bone Mineral Density (BMD) in Postmenopausal Women
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Lee Seung-Hun
Koh Jung-Min
Park Byung-Rae
Shin Hyoung-Doo
Kim Tae-Ho
Park Eui-Kyun
Kim Shin-Yoon
Kim Ghi-Su
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Abstract
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Objective: Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulator of bone metabolism, by mediating osteoclastogenesis, mechanotransduction, bone formation and fracture repair. We examined the association between PTGS2 gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women.
Methods: From the results of previous reports, we selected two polymorphisms, that is, -1329A>G at the promoter region and +6365T>C at the 3’-untranslated region, and we genotyped -1329A>G using single-base extension (SBE) reaction and +6365T>C using TaqMan method. BMD at the lumbar spine and femur neck was measured using dual energy X-ray absorptiometry.
Results: Mean age for the subjects was 58.9 years old. The frequencies of the minor alleles of the two polymorphisms were 47.4% for -1329G, and 20.3% for +6365C. Both polymorphisms were in compliance with Hardy-Weinberg equilibrium. PTGS2 -1329A>G didn’t show any significant correlations with the BMD in either site, and PTGS2 +6365T>C didn’t show any significant correlation with lumbar spine BMD. Multiple regression analysis showed that PTGS2 +6365T>C polymorphism was associated with BMD at the femur neck, even after controlling for age, weight, height, and years since menopause (P=0.03). The subjects with C allele had significantly lower femur neck BMD than those with T homozygote.
Conclusion: These findings indicate that PTGS2 could be a candidate gene for the determinant for BMD in Korean postmenopausal women.
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KEYWORD
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Bone density, Polymorphism, Postmenopausal women, Prostaglandin-endoperoxide synthase 2
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